M Is For MDR1 (Shetland Sheepdog) ~ A to Z Blogging Challenge 2020

Certain dog breeds, such as the Shetland Sheepdog (aka the Sheltie) can be born with a genetic mutation that hinders their ability to remove certain drugs from the brain. This means that certain medications can cause a build up of toxins in the brain and this may cause severe adverse reactions. Having the Multidrug Resistance mutation (MDR1) gene and taking certain veterinary drugs may cause neurological reactions, tremors, disorientation, lack of muscle control or even death.

It’s important to research your specific breed to make sure you know about any genetic predispositions. If your dog falls into the MDR1 gene family, testing should be done before giving certain medications that contain Ivermectin.

Message from a Sheltie mom– I am so glad that I researched about Shetland Sheepdogs before I got Misty Blue. Being a first time Sheltie mom, I would have never known about the MDR1 gene and the interactions with certain medications that could have caused her harm.

I found Misty Blue didn’t have the mutated MDR1 gene by a DNA test. I was very pleased with Wisdom Panel, but you can have your pup tested through your veterinarian or other DNA test kits.

Have you had your Sheltie tested for the MDR1 gene?

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